We extended the SALEM-LS tool for allowing also the detection of lupus lesions. Specifically, given the specific properties of the lupus lesions, we include in the post-processing steps that reduce possible false positive detections, a new constraint based on lesion location. Since the posterior fossa is an uncommon location for WML in neurolupus, we discarded lesions found there by using an in-house atlas, which was segmented into 12 brain structures including the posterior fossa. The tool has been validated using 20 patients acquired with different scanners.
The "useful resources" section contains the software source code in a zip file and a link to the SPM framework. Currently, the tool is implemented as a Matlab script using SPM directives, although its final version will be integrated in SPM as a new add-on.